Microarray analysis of Epidermolysis bullosa simplex-mottled pigmentation

ABSTRACT: The goal of this study is to characterize the expression profile of Epidermolysis bullosa simplex-mottled pigmentation (EBS-MP) patient compared with normal subjects using genomic expression analyses. Microarray analyses were performed with RNA isolated from skin biopsies. Robust multiarray analysis (RMA) normalization and Smyth’s moderated t test were used to select differentially expressed genes. Expression profiling comparisons show that 52 genes are differentially expressed in EBS-MP patients compared to control subjects. Difference of expression for three genes (TYR, CCL22 , and ACVR1C ) was validated using real-time reverse transcription–polymerase chain reaction. Twelve genes were related to lipid biosynthesis process, two to keratinisation and skin pigmentation, Nineteen to cell g

ORGANISM(S): Homo sapiens

SUBMITTER: Catherine Laprise 

PROVIDER: E-GEOD-36406 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress