Parallel selection mapping using artificially selected mice reveals body weight control loci (SNP)

ABSTRACT: Understanding how polygenic traits evolve and respond to selection is a major unsolved problem, because challenges exist for identifying genes underlying a complex trait and understanding how multi-locus selection operates in the genome. Here we used artificial selection experiments to study polygenic response to selection. Inbred strains from seven independent long-term selection experiments in mice for extreme bodyweight (“High” lines weigh 77-42g vs. 40-16g in “Controls” lines), were genotyped at 527,572 SNPs to identify genetic variants controlling bodyweight. We identified 67 high-resolution parallel selected regions (PSRs) where multiple High lines share variants rarely found among the Controls. By comparing allele frequencies in one selection experiment against its unselected contro

ORGANISM(S): Mus musculus

SUBMITTER: Yingguang Frank Chan 

PROVIDER: E-GEOD-36409 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress