The MET oncogene is a functional marker of a glioblastoma stem cell subtype and drives the invasive phenotype

ABSTRACT: Eighteen independent neurospheres derived from patients affected by primary glioblastoma were grouped into “classical”, “mesenchymal” or “proneural” subtypes according to analysis of genetic lesions and gene expression profiling. Here we show that expression of the MET oncogene, encoding the tyrosine kinase receptor for HGF, associates with mesenchymal and proneural neurospheres (Met-pos-NS). Met expression is almost absent from classical neurospheres (Met-neg-NS), and mutually exclusive with amplification and expression of the EGF receptor gene. Met-pos-NS and Met-neg-NS display distinct growth factor requirements, differentiate along divergent pathways, and generate tumors with distinctive histological features. Met-pos-NS contain a variable percentage of Met positive (Methigh) and Met n

ORGANISM(S): Homo sapiens

SUBMITTER: Enzo Medico 

PROVIDER: E-GEOD-36426 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress