Genome-wide analysis of renal gene expression during hyperoxaluria development

ABSTRACT: Previous studies have proposed that production of reactive oxygen species (ROS) is an important contributor to renal injury and inflammation following exposure to oxalate or calcium-oxalate crystals. The present study was conducted to determine, utilizing global transcriptome analyses, if the NADPH oxidase system is activated in kidneys of rats fed a diet leading to hyperoxaluria and crystal deposition. HLP was used to induce hyperoxaluria. Hyperoxaluria will lead to crystallization and up regulation of various NADPH oxidase subunits followed by increased expression of different specific genes. It is our hypothesis that crystallization induces inflammation of the kidneys via the activation of renin-angiotensin system (RAS) and production of reactive oxygen species (ROS) through NADPH oxid

ORGANISM(S): Rattus norvegicus

SUBMITTER: Sunil Joshi 

PROVIDER: E-GEOD-36446 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress