Affymetrix 250K StyI SNP array data for gastric and esophageal adenocarcinoma cancer types

ABSTRACT: Using data from high-density genomic profiling arrays, we describe the profiles of somatic copy-number aberrations (SCNAs) in 486 adenocarcinomas across all three major digestive organs, including 296 gastric and esophageal cancers. This analysis revealed that although patterns of broad, chromosome arm-level alterations are similar across the three types of adenocarcinoma, focal genomic amplifications are substantially more prevalent in gastric/esophageal adenocarcinoma. A statistical analysis identified 64 regions of significantly recurrent amplification and deletion, including those shared across these tumors and those uniquely significant in adenocarcinomas from a single organ. Among significantly amplified genes are those encoding therapeutically targetable kinases such as ERBB2, FGFR

ORGANISM(S): Homo sapiens

SUBMITTER: Steven Schumacher 

PROVIDER: E-GEOD-36459 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress