Histopathological stages of disease in Helicobacter-induced mucosa-associated lymphoid tissue lymphoma.

ABSTRACT: Long-term colonization of humans with Helicobacter pylori can cause the development of gastric B cell mucosa-associated lymphoid tissue lymphoma, yet little is known about the sequence of molecular steps that accompany disease progression. We used microarray analysis and laser microdissection to identify gene expression profiles characteristic and predictive of the various histopathological stages in a mouse model of the disease. The initial step in lymphoma development is marked by infiltration of reactive lymphocytes into the stomach and the launching of a mucosal immune response. Our analysis uncovered molecular markers of both of these processes, including genes coding for the immunoglobulins and the small proline-rich protein Sprr 2A. The subsequent step is characterized histologicall

ORGANISM(S): Mus musculus

SUBMITTER: Anne Mueller 

PROVIDER: E-GEOD-3648 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress