Id proteins synchronize stemness and anchorage to the niche of neural stem cells

ABSTRACT: Stem cell functions require activation of stem cell-intrinsic transcriptional programs as well as intimate extracellular interactions with a niche microenvironment. How the core pluripotency transcriptional machinery controls residency of stem cells in the niche microenvironment is unknown. Here we show that the helix loop helix transcriptional regulators Id (Inhibitors of DNA binding) are the master regulators that coordinate stem cell activities with anchorage of neural stem cells (NSCs) to the embryonic and postnatal niche. Conditional inactivation of Id genes (Id1, Id2 and Id3) in the mouse NSC compartment triggered detachment of embryonic and post-natal NSCs from the ventricular and vascular niche respectively, followed by premature differentiation. Through an unbiased interrogation o

ORGANISM(S): Mus musculus

SUBMITTER: Mario Lauria 

PROVIDER: E-GEOD-36488 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress