Expression analyses in Drosophila young virgin female ovary

ABSTRACT: Insulators delimit independent transcriptional domains within genomes by constraining enhancer and silencer action. These transcriptional effects depend upon DNA recognition by insulator binding proteins that recruit partners that protect against inappropriate long range modulation of non-target promoters. Insulator binding proteins are broadly expressed during development, with largely constitutive binding to thousands of genomic sites. Yet, tissue-specific transcriptional changes result from the loss of individual insulator binding proteins. To understand the molecular basis for such effects, we are studying the classic Drosophila insulator protein Suppressor of Hairy-wing [Su(Hw)]. Genetic studies show that loss of this broadly expressed insulator protein prevents oocyte development.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Alexey Soshnev 

PROVIDER: E-GEOD-36528 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress