Mll1 regulates the downstream gene transcription activated by TNFa

ABSTRACT: Genes of mixed lineage leukemia family regulate transcription via methylating histone H3K4. we studied the role of MLL1 in innate immunity and found it selectively regulates the activation of NF-kB downstream genes mediated by TNFa. Mll1+/+ and Mll1-/- MEF cells were treated for 4 hr with 10ng/ml TNFa or control solution respectively. The same treatment were performed three times independently and the harvested cells of same treatment were mixed together and submitted for high throughput sequencing.

ORGANISM(S): Mus musculus

SUBMITTER: Min Wu 

PROVIDER: E-GEOD-36567 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress