Melanoma-derived exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through upregulation of the MET oncoprotein.

ABSTRACT: Tumor-derived exosomes are emerging as mediators of tumorigenesis with a tissue-specific address and message. We explored the function of melanoma-derived exosomes in formation of primary tumors and metastatic progression in both murine models and patients. Whereas exosomes from highly metastatic melanoma cells increased the metastatic behavior of primary tumor cells by educating bone marrow (BM) progenitor cells via the MET receptor, exosomes from low metastatic melanoma cells did not alter the incidence of metastases. Melanoma-derived exosomes induced vascular leakiness at pre-metastatic sites, and reprogrammed BM progenitor cells towards a pro-vasculogenic phenotype (c-Kit+Tie2+MET+). Reducing MET expression in tumor-derived exosomes diminished the pro-metastatic behavior of BM cells. I

ORGANISM(S): Mus musculus

SUBMITTER: Gema Moreno-Bueno 

PROVIDER: E-GEOD-36584 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress