Transcriptional events during lung recovery from MRSA infection: a mouse pneumonia model

ABSTRACT: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging threat to human health throughout the world. Rodent MRSA pneumonia models mainly focus on the early innate immune responses to MRSA infection. However, the molecular pattern and mechanisms of recovery from MRSA lung infection are largely unknown. In this study, a nonlethal mouse MRSA pneumonia model was employed to investigate events during lung recovery from MRSA infection. We compared lung bacterial clearance, bronchoalveolar lavage fluid (BALF) characterization, lung histology, and gene expression profiling between Day 1 and Day 3 post-MRSA infection. Compared to Day 1 post-infection, bacterial colony counts and both BALF total cell number and protein concentration significantly decreased at Day 3

ORGANISM(S): Mus musculus

SUBMITTER: Jiwang Chen 

PROVIDER: E-GEOD-36587 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress