SOX2 gene regulates the transcriptional network of oncogenes and affects tumorigenesis of human lung cancer cells

ABSTRACT: Recent studies demonstrated that cancer stem cells (CSCs) have higher tumorigenesis properties than those of differentiated cancer cells and that transcriptional factor-SOX2 plays a vital role in maintaining the unique properties of CSCs; however, the function and underlying mechanism of SOX2 in carcinogenesis of lung cancer are still elusive. This study applied immunohistochemistry to analyze the expression of SOX2 in human lung tissues of normal individuals as well as patients with adenocarcinoma, squamous cell carcinoma, large cell and small cell carcinoma and demonstrated specific overexpression of SOX2 in all types of lung cancer tissues. This finding supports the notion that SOX2 contributes to the tumorigenesis of lung cancer cells and can be used as a diagnostic probe. In addition,

ORGANISM(S): Homo sapiens

SUBMITTER: NA LI 

PROVIDER: E-GEOD-36597 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress