MiRNA expression during in vitro mouse T cell activation (D011.10+ CD4 T cells)
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Andrea Barczak
PROVIDER: E-GEOD-36607 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.
Bronevetsky Yelena Y Villarino Alejandro V AV Eisley Christopher J CJ Barbeau Rebecca R Barczak Andrea J AJ Heinz Gitta A GA Kremmer Elisabeth E Heissmeyer Vigo V McManus Michael T MT Erle David J DJ Rao Anjana A Ansel K Mark KM
The Journal of experimental medicine 20130204 2
Activation induces extensive changes in the gene expression program of naive CD4(+) T cells, promoting their differentiation into helper T cells that coordinate immune responses. MicroRNAs (miRNAs) play a critical role in this process, and miRNA expression also changes dramatically during T cell differentiation. Quantitative analyses revealed that T cell activation induces global posttranscriptional miRNA down-regulation in vitro and in vivo. Argonaute (Ago) proteins, the core effector proteins ...[more]
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