Transcriptomal effects of four-day exposure to estradiol on mouse primary culture urogenital sinus mesenchymal cells of fetal mouse prostate

ABSTRACT: Developmental exposure of mouse fetuses to estrogens results in dose-dependent permanent effects on prostate morphology and function. Fetal prostatic mesenchyme cells express estrogen receptor alpha (ERα) and androgen receptors and convert stimuli from estrogens and androgens into signaling to regulate epithelial cell proliferation and differentiation. To obtain mechanistic insight into the role of different doses of estradiol (E2) in regulating mesenchymal cells, we examined E2-induced transcriptomal changes in primary cultures of fetal mouse prostate mesenchymal cells. Urogenital sinus mesenchyme cells were obtained from male mouse fetuses at gestation day 17 and exposed to 10 pM, 100 pM or 100 nM E2 in the presence of a physiological concentration of dihydrotestosterone (0.69 nM) for fo

ORGANISM(S): Mus musculus

SUBMITTER: Toshi Shioda 

PROVIDER: E-GEOD-36630 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress