Developmental shifts in gene expression in the auditory forebrain during the sensitive period for song learning

ABSTRACT: A male zebra finch begins to learn to sing by memorizing a tutorM-bM-^@M-^Ys song during a sensitive period in juvenile development. Tutor song memorization requires molecular signaling within the auditory forebrain. Using microarray and in situ hybridizations, we tested whether the auditory forebrain at an age just before tutoring expresses a different set of genes compared with later life after song learning has ceased. Microarray analysis revealed differences in expression of thousands of genes in the male auditory forebrain at posthatch day 20 (P20) compared with adulthood. Furthermore, song playbacks had essentially no impact on gene expression in P20 auditory forebrain, but altered expression of hundreds of genes in adults. Most genes that were song-responsive in adults were expresse

ORGANISM(S): Taeniopygia guttata

SUBMITTER: Kirstin Replogle 

PROVIDER: E-GEOD-36657 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress