Transcription profiling of paraventricular hypothalamic nucleus (PVH) from mice stimulated by either LPS injection or restraint to understand the molecular mechanisms in the modulation of PVH responses to categorically distinct stressors.

ABSTRACT: The paraventricular hypothalamic nucleus (PVH) is a key site for integrating neuroendocrine, autonomic, and behavioral adjustments to diverse homeostatic challenges, including physiological (e.g., infection or hemorrhage) and emotional [e.g., restraint (RST) or footshock] stresses. Both types of challenges ultimately converge to activate common response systems represented in PVH, including the hypothalamo-pituitary-adrenal axis and the sympathoadrenal system. Oligonucleotide microarrays (U74A; Affymetrix, Santa Clara, CA) were used to compare and contrast gene expression profiles in the PVH elicited at 1 and 3 hr after acute exposure to representative physiological [intraperitoneal injection of 10 microg lipopolysaccharide (LPS)] and emotional (30 min RST) stressors. In general, the two c

ORGANISM(S): Mus musculus

SUBMITTER: John Robert Walker 

PROVIDER: E-GEOD-367 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress