Unknown,Transcriptomics,Genomics,Proteomics

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BEAF-32 insulator regulates gene expression of genes involved in cell polarity and neoplastic growth.


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE36735: Distribution of Drosophila insulator protein BEAF-32 in Wing imaginal tissue (Wildtype) [ChIP-seq] GSE36736: Genome wide transcriptional profiling of BEAF-32 in wing imaginal tissues of wildtype and mutants [expresion array] Refer to individual Series

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Gurudatta Baraka Vishwanathan 

PROVIDER: E-GEOD-36737 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The BEAF insulator regulates genes involved in cell polarity and neoplastic growth.

Gurudatta B V BV   Ramos Edward E   Corces Victor G VG  

Developmental biology 20120626 1


Boundary Element Associated Factor-32 (BEAF-32) is an insulator protein predominantly found near gene promoters and thought to play a role in gene expression. We find that mutations in BEAF-32 are lethal, show loss of epithelial morphology in imaginal discs and cause neoplastic growth defects. To investigate the molecular mechanisms underlying this phenotype, we carried out a genome-wide analysis of BEAF-32 localization in wing imaginal disc cells. Mutation of BEAF-32 results in miss-regulation  ...[more]

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