Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis in telomerase-proficient mice

ABSTRACT: Background and Aims: Telomere dysfunction can increase tumor initiation by induction of chromosomal instability, but initiated tumor cells need to reactivate telomerase for genome stabilization and tumor progression. However, this concept has not been proven in vivo since appropriate mouse models were lacking. Here, we analyzed hepatocarcinogenesis (i) in a novel mouse model of inducible telomere dysfunction on a telomerase-proficient background, (ii) in telomerase knockout mice with chronic telomere dysfunction (G3 mTerc-/-), and (iii) in wild-type mice with functional telomeres and telomerase. Transient or chronic telomere dysfunction enhanced the rates of chromosomal aberrations during hepatocarcinogenesis, but only telomerase-proficient mice exhibited significantly increased rates of m

ORGANISM(S): Mus musculus

SUBMITTER: Hans Kestler 

PROVIDER: E-GEOD-36813 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress