DNA Methylation Dynamics in Blood after Hematopoietic Cell Transplant

ABSTRACT: Classically, epigenetic deregulation is considered a common hallmark of cancer. Nevertheless, recent publications have demonstrated its association with a large array of human diseases such as autoimmune disorders and environmental factors such as diet. Despite the increasing relevance of DNA methylation for the study of critical biological processes and for the development of novel biomarkers, DNA methylation analysis applied to the study of hematopoietic cell transplantation (HCT) has not yet been explored. Here, we analyzed global DNA methylation in blood samples by using a pyrosequencing based methylation assay of repetitive DNA elements (LINE1 and NBL2) in a cohort of 47 patients with allogenic HCT up to 12 months post-HCT. We observed that the recipients stably maintained the donor’s

ORGANISM(S): Homo sapiens

SUBMITTER: Ramon Rodriguez 

PROVIDER: E-GEOD-36832 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress