Hypoxia effect on human umbilical vein endothelial cells - gene and exon expression
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Julia Weigand
PROVIDER: E-GEOD-36837 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Hypoxia-induced alternative splicing in endothelial cells.
Weigand Julia E JE Boeckel Jes-Niels JN Gellert Pascal P Dimmeler Stefanie S
PloS one 20120802 8
<h4>Background</h4>Adaptation to low oxygen by changing gene expression is vitally important for cell survival and tissue development. The sprouting of new blood vessels, initiated from endothelial cells, restores the oxygen supply of ischemic tissues. In contrast to the transcriptional response induced by hypoxia, which is mainly mediated by members of the HIF family, there are only few studies investigating alternative splicing events. Therefore, we performed an exon array for the genome-wide ...[more]
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