ICGC Pancreas: Genomic analysis reveals roles for chromatin modification and axonguidance in pancreatic cancer

ABSTRACT: Pancreatic cancer (PC) is the fourth leading cause of cancer death with an overall 5-year survival rate of < 5%, a statistic that has changed little in almost 50 years. A deeper understanding of the underlying molecular pathophysiology is expected to advance the urgent need to develop novel therapeutic and early detection strategies for this disease. Genomic characterisation of PC has previously relied on targeted PCR based exome sequencing of small cohorts of mixed primary and metastatic lesions propagated as xenografts or cell lines (Jones et al, Science 321:1801-1806), leaving the true mutational spectrum of the clinical disease largely unresolved. Here we use exome sequencing (https://www.ebi.ac.uk/ega/studies/EGAS00001000154) and copy number analysis (not submitted) to define genomic

ORGANISM(S): Homo sapiens

SUBMITTER: Mark Cowley 

PROVIDER: E-GEOD-36924 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress