Mycobacterium tuberculosis Requires Phosphate-Responsive Gene Regulation to Resist Host Immunity

ABSTRACT: Mycobacterium tuberculosis persists in the lungs of mammalian hosts despite inducing an immune response dominated by the macrophage-activating cytokine interferon-gamma (IFN-gamma). We identified the M. tuberculosis phosphate uptake system component PstA1 as a factor required to resist IFN-gamma dependent immunity. A ∆pstA1 mutant was fully virulent in IFN-gamma-/- mice but was attenuated in mice lacking the IFN-gamma-inducible nitric oxide synthase (NOS2). This phenotype suggests that ∆pstA1 bacteria are hypersensitive to an IFN-gamma-dependent immune mechanism(s) other than NOS2. In other species, the Pst system participates in phosphate-responsive gene regulation by interacting with a two-component signal transduction system. We identified genes that exhibited dysregulated expressi

ORGANISM(S): Mycobacterium tuberculosis str. Erdman = ATCC 35801

SUBMITTER: Martin Voskuil 

PROVIDER: E-GEOD-36998 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress