Polarity gene alterations in pure invasive micropapillary carcinomas of the breast

ABSTRACT: In this study we have identified a new morphological pattern in IMPC defined by the presence of numerous bi-nucleated cells, related to abnormal expression of genes involved in regulation of mitosis. We also demonstrated that IMPC presented tight and adherens junctions proteins expression modifications that could participate to their clinical behavior. We showed that IMPC was associated with a specific genomic profile compared to ER+ grade-matched IDC consisting of gains of 17q, high rates of 17q23 and 17q12 ERBB2 amplifications, losses of heterozygosity of 6q. The putative role of the genes located in this 6q LOH should be further investigated in order to determine if they could play a role in the presence of numerous bi-nucleated cells and inverted p

ORGANISM(S): Homo sapiens

SUBMITTER: Jaydutt Bhalshankar 

PROVIDER: E-GEOD-37035 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress