Gene expression changes associated with the airway wall response to injury

ABSTRACT: Understanding the way in which the airway heals in response to injury is fundamental to dissecting the mechanisms underlying airway disease pathology. Only limited data is available in relation to in vivo characterisation of the molecular features of repair in the airway. This study sought to characterise the dynamic changes in gene expression that are associated with airway repair in response to physical injury. Gene expression changes in the airway wall following bronchial brush biopsy were profiled in anaesthetised sheep. The experimental design featured sequential studies in the same animals (n=8) over the course of a week and yielded data relating to the repair process at 6 hours, and 1, 3 and 7 days after injury. Notable features of the transcriptional response included the early an

ORGANISM(S): Ovis aries

SUBMITTER: David Collie 

PROVIDER: E-GEOD-37086 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress