Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

10 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling of mouse mammary epithelial stem cells and differentiated derivatives

ABSTRACT: Gene Expression Profiling of Murine Mammary Stem Cells and Differentiated Derivatives.

ORGANISM(S): Mus musculus

SUBMITTER: Ontario Genomics Innovation Centre (OGIC)

PROVIDER: E-GEOD-3711 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

Purification and unique properties of mammary epithelial stem cells.

Stingl John J Eirew Peter P Ricketson Ian I Shackleton Mark M Vaillant François F Choi David D Li Haiyan I HI Eaves Connie J CJ

Nature 20060104 7079

Elucidation of the cellular and molecular mechanisms that maintain mammary epithelial tissue integrity is of broad interest and paramount to the design of more effective treatments for breast cancer. Evidence from both in vitro and in vivo experiments suggests that mammary cell differentiation is a hierarchical process originating in an uncommitted stem cell with self-renewal potential. However, analysis of the properties and regulation of mammary stem cells has been limited by a lack of methods ...[more]

PMID: 16395311

Similar Datasets

Transcription profiling of mouse sorted bone marrow samples to determine genes implicated in hematopoetic stem cell identity

Project description:Gene expression profiles of sorted bone marrow samples to determine genes implicated in hematopoetic stem cell identity. Experiment Overall Design: this experiment include 6 samples and 32 replicates

2008-06-12 | E-GEOD-3234 | biostudies-arrayexpress

Transcription profiling of mouse pluripotet embyonal carcinoma cells

Project description:Investigation of very early events required for initiating differentiation of pluripotent embryonal carcinoma cells - the effect of cell aggregation on gene expression. Experiment Overall Design: this experiment include 4 samples and 24 replicates

2008-06-12 | E-GEOD-4085 | biostudies-arrayexpress

Transcription profiling of human and mouse first passage vs. primary retinal sphere cells

Project description:The pigmented portion of ciliary epithelium in the adult mammalian eye harbors mitotically quiescent retinal sphere cells, which are capable of self-renewal and differentiating into retinal neurons when assayed in vitro; however, very little is known about the molecular mechanism controlling the proliferation and differentiation of these adult retinal stem cells or their molecular resemblance to mutipotent stem/progenitor cells during early eye development. This experiment studies the gene expression of first passage and primary human and mouse retinal sphere cells. Experiment Overall Design: this experiment include 4 samples and 12 replicates

2008-06-12 | E-GEOD-3791 | biostudies-arrayexpress

Transcription profiling of murine J1 embryonic stem cells undergoing a differentiation time course to study changes in transcription during stem cell differentiation

Project description:An 11-point time course study on differentiating embryoid bodies from a murine J1 embryonic stem cell line. The time course includes 0 hr, 6 hr, 12 hr, 18 hr, 24 hr, 36 hr, 48 hr, 4 days, 7 days, 9 days and 14 days. Experiment Overall Design: this experiment includes 11 samples and 66 replicates.

2007-12-14 | E-GEOD-3749 | biostudies-arrayexpress

Transcription profiling of mouse undifferentiated and differentiated mammospheres isolated from FVB animaks

Project description:Mammary gland cells were isolated from 5-8 week old FVB mice and allowed to proliferate as undifferentiated mammospheres in the presence of growth factors (bFGF and EGF). Comparison of the gene expression profiles of undifferentiated mammospheres vs. mammospheres that were allowed to differentiate for 6 days by the removal of growth factors will help to identify genes that are implicated in the maintenance of the mammary gland stem cell compartment. Experiment Overall Design: this experiment include 2 samples and 12 replicates

2008-06-12 | E-GEOD-3777 | biostudies-arrayexpress

Transcription profiling of mouse pRb null primary myoblasts and myotubes will provide a global picture of the downstream targets of pRb transcriptional regulation in relation to cell cycle control, apoptosis inhibition, and muscle differentiation

Project description:Satellite cells play an important role in post-natal growth and regeneration of skeletal muscle. They can be defined as a population adult muscle stem cells based on their self renewal capability and ability to differentiate into skeletal muscle fibers. Functional Retinoblastoma protein (pRb) is essential for the process of skeletal muscle differentiation in satellite cell derived primary myoblasts. Furthermore, the biochemical function of pRb is largely associated with its ability to interact with chromatin modifying factors such as histone deacetylases (HDACs) and histone methyltransferases thus inhibiting transcription of target gene promoters. Hence, expression profiling of pRb null primary myoblasts and myotubes will provide a global picture of the downstream targets of pRb transcriptional regulation in relation to cell cycle control, apoptosis inhibition, and muscle differentiation. Experiment Overall Design: This experiment includes 4 samples with 3 replicates each on 2 platforms for a total of 24 Samples.

2008-04-08 | E-GEOD-10428 | biostudies-arrayexpress

Transcription profiling of mouse embryonic stem cells grown in a maintenance serum vs. a non-maintenance serum

Project description:Two sets of RNA samples were generated from 3 days growth in different serum lots, lot 6999 and lot 6473. Lot 6999 has been pre-screened for embryonic stem cell maintenance and is routinely used for that purpose. Lot 6473 failed all tests for embryonic stem cell maintenance. Experiment Overall Design: this experiment include 2 samples and 12 replicates

2008-06-12 | E-GEOD-3774 | biostudies-arrayexpress

Transcription profiling of human embryonic skeletal myoblasts

Project description:Skeletal muscle cells (myoblasts - human fetal cells from 17 week old embryo) Experiment Overall Design: this experiment include 1 samples and 6 replicates

2008-06-12 | E-GEOD-3230 | biostudies-arrayexpress

Transcription profiling of human megakaryotic and fibroblast cell lines that have been transduced with either Smad7 recombinant retroviral vector vs control

Project description:Smad7 is a member of the TGF-B superfamily that plays a signigicant role in fate determination of hematopoietic stem cells. This experiment compares expression between megakaryotic and fibroblast cell lines that have been transduced with either Smad7 recombinant retroviral vector or retroviral vector alone. Experiment Overall Design: this experiment include 4 samples and 30 replicates

2008-06-12 | E-GEOD-3771 | biostudies-arrayexpress

Transcription profiling of mouse osteoblast differentiation - time series

Project description:Differentiation Time Course; examination of osteoblast differentation by comparing cells exposed to growth factors with ctrl cells. Experiment Overall Design: this experiment include 7 samples and 42 replicates

2008-06-12 | E-GEOD-3792 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data