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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Differentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart3]

ABSTRACT: Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence 2-condition experiment: blastocyst (B) AND embryo of poor quality (E).

ORGANISM(S): Homo sapiens

SUBMITTER: Raluca TEUSAN

PROVIDER: E-GEOD-37116 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genomic assessment of human cumulus cell marker genes as predictors of oocyte developmental competence: impact of various experimental factors.

Feuerstein Prisca P Puard Vincent V Chevalier Catherine C Teusan Raluca R Cadoret Veronique V Guerif Fabrice F Houlgatte Remi R Royere Dominique D

PloS one 20120727 7

<h4>Background</h4>Single embryo transfer (SET) is the most successful way to reduce the frequency of multiple pregnancies following in vitro fertilisation. However, selecting the embryo for SET with the highest chances of pregnancy remains a difficult challenge since morphological and kinetics criteria provide poor prediction of both developmental and implantation ability. Partly through the expression of specific genes, the oocyte-cumulus interaction helps the oocyte to acquire its development ...[more]

PMID: 22848380

Similar Datasets

Differentiating factors of cumulus cells related to quality of the human oocyte

Project description:Single embryo transfer (SET) is the most successful way to reduce the frequency of multiple pregnancies during in vitro fertilisation. However, selecting the embryo with the highest chances of pregnancy for SET remains a difficult challenge, since morphological and kinetics criteria provide poor prediction of both developmental and implantation ability. Partly through the expression of specific genes, the oocyte-cumulus interaction helps the oocyte to acquire its developmental competence. Our aim was therefore to identify at the level of cumulus cells (CCs) any genes related to oocyte developmental competence. This SuperSeries is composed of the SubSeries listed below. Refer to individual Series.

2012-12-10 | E-GEOD-37277 | biostudies-arrayexpress

Differentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart2]

Project description:Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence 2-condition experiment: blastocyst (B) ans embryo of poor quality (E).

2012-12-10 | E-GEOD-37117 | biostudies-arrayexpress

Differentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart1]

Project description:Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence three-condition experiment: blastocyst (B), embryo of poor quality (E) AND immature oocytes (VG).

2012-12-10 | E-GEOD-37110 | biostudies-arrayexpress

Differentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart2]

Project description:Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence

2012-12-10 | GSE37117 | GEO

Differentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart1]

Project description:Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence

2012-12-10 | GSE37110 | GEO

Differentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart3]

Project description:Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence

2012-12-10 | GSE37116 | GEO

Differentiating factors of cumulus cells related to quality of the human oocyte

2012-12-10 | GSE37277 | GEO

Transcriptional profiling of cumulus cells differentiation throughout oocyte competence acquisition in the murine ovarian follicles.

Project description:Cumulus cells surrounding the oocyte were sampled at the following stages: developmentally incompetent or poorly competent prophase I oocytes (NC1 oocytes), developmentally competent prophase I oocytes (C1 oocytes), and developmentally competent metaphase II oocytes (C2 oocytes). NC1 samples were collected from immature, unexpanded cumulus-oocytes complexes (COC) from prepubertal (3-week-old) mice, C1 samples from immature, unexpanded cumulus-oocytes complexes (COC) from adult (8-week-old) and C2 samples from mature, expanded COCs obtained from the oviduct from 8-week-old mice after standard superovulation protocol. Global transcriptional profiling was performed using cumulus cells collected from murine ovarian follicles during in vivo oocyte developmental competence acquisition. Cumulus cells were collected at 3 stages: early stage follicles (prophase I arrested oocytes, meiotically competent but developmentally incompetent, n=5), late stage follicles (prophase I arrested oocytes, meiotically competent and developmentally competent, n=5) and ovulatory follicles collected in vivo (metaphase II arrested oocytes, developmentally fully competent, n=5).

2012-10-14 | E-GEOD-36604 | biostudies-arrayexpress

Assessing transcriptomes of mouse cumulus cells, mural granulosa cells, and cumulus-oocyte complexes

Project description:Transcriptomes of mouse mural granulosa cells were sequenced to identify transcripts expressed in mural granulosa cells of ovaries. Moreover, transcriptomes of cumulus cells were compared between those of young (2 month-old) and old mice (10 month-old) to assess the effects of ageing on cumulus cells. In addition, transcriptomes of cumulus-oocyte complexes were compared between DBA/2 and (C57BL/6 x DBA/2)F1 mice to assess the strain differences.

2016-04-15 | GSE80326 | GEO

Palmitoylated proteins in bovine ovarian cumulus-oocyte complexes

Project description:The palmitoyl-proteome of bovine cumulus-oocyte complexes (COCs) cells was investigated by combining acyl-biotin exchange chemistry and quantitative mass spectrometry analysis.

2022-02-15 | PXD020540 | Pride

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