Xenobiotics and loss of cell adhesion drives distinct transcriptional outcomes by Aryl hydrocarbon Receptor (AhR) signaling.

ABSTRACT: The Aryl hydrocarbon Receptor (AhR) is a signal regulated transcription factor, which is canonically activated by the direct binding of xenobiotics. In addition, switching cells from adherent to suspension culture also activates the AhR, representing a non-xenobiotic, physiological activation of AhR signaling. Here, we show that the AhR is recruited to target gene enhancers in both ligand (YH439) treated and suspension cells, suggesting a common mechanism of target gene induction between these two routes of AhR activation. However, gene expression profiles critically differ between xenobiotic and suspension activated AhR signaling. Por, and Cldnd1 were regulated predominately by ligand treatments, while in contrast, ApoER2 and Ganc were regulated predominately by the suspension condition.

ORGANISM(S): Mus musculus

SUBMITTER: Kian Leong LEE 

PROVIDER: E-GEOD-37144 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress