Gene expression profiling reveals mast cell-dependent inflammation in the meninges in early EAE.

ABSTRACT: The meninges are generally considered relatively inert tissues that house the CSF and provide protection for the brain and spinal cord. However, our previous studies using Kit mutant (Kit W/Wv) mast cell-deficient mice demonstrated that mast cells residing in the dura mater and pia mater exacerbate the severity of experimental autoimmune encephalomyelitis (EAE), the rodent model of the CNS demyelinating disease, multiple sclerosis. These data suggest that the meninges are sites of active immune responses in disease. Gene expression profiles of meningeal tissue from wild type and mast cell deficient mice prior to and at day 6 post-EAE induction were found highly distinct. Increases in both mast cell- and neutrophil-associated transcripts were among the notable disease-related changes observ

ORGANISM(S): Mus musculus

SUBMITTER: Martin Hessner 

PROVIDER: E-GEOD-37191 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress