Expression data from aquatic axolotl full thickness epithelial flank wounds, innervated limbs, and denervated limbs collected over seven days

ABSTRACT: Salamander limb regeneration is dependent upon tissue interactions that are local to the amputation site. Communication among limb epidermis, peripheral nerves, and mesenchyme coordinate cell migration, cell proliferation, and tissue patterning to generate a blastema, a mass of progenitor cells that forms missing limb structures. An outstanding question is how molecular cross-talk between these tissues gives rise to the regeneration blastema. To identify genes associated with epidermis-nerve-mesenchymal interactions during limb regeneration, we examined histological and transcriptional changes during the first week following injury in the wound epidermis and subjacent cells between three injury types; 1) a flank wound on the side of the animal that will not regenerate a limb, 2) a denervat

ORGANISM(S): Ambystoma mexicanum

SUBMITTER: James Monaghan 

PROVIDER: E-GEOD-37198 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress