The Stat3/GR interaction code: predictive value of direct/indirect DNA recruitment for transcription outcome

ABSTRACT: Transcription factor recruitment to genomic sites of action is primarily due to direct protein:DNA interactions. The subsequent recruitment of co-regulatory complexes leads to either transcriptional activation or repression. In contrast to this canonical scheme, some transcription factors such as the glucocorticoid receptor (GR) behave as transcriptional repressors when recruited to target genes through protein tethering. We have investigated the genome-wide prevalence of tethering between GR and Stat3 and found non-reciprocal interactions, namely that GR tethering to DNA-bound Stat3 results in transcriptional repression whereas Stat3 tethering to GR results in synergism. Further, other schemes of GR and Stat3 co-recruitment to regulatory modules result in transcriptional synergism, includ

ORGANISM(S): Mus musculus

SUBMITTER: David Langlais 

PROVIDER: E-GEOD-37235 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress