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Gene expression analysis of murine SAMHD1 deficient peritoneal macrophages

ABSTRACT: To elucidate responses of myeloid cells to SAMHD1 deficiency in the absence of exogenous viral infection, we performed global gene expression analysis of SAMHD1 deficient macrophages. Peritoneal macrophages from nine mutants and nine controls were FACS sorted. Cells from three animals were pooled to yield three poolls per group. RNA from these pools was subjected to next generation mRNA sequencing

ORGANISM(S): Mus musculus

SUBMITTER: Tina Schumann

PROVIDER: E-GEOD-37236 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression analysis of murine peritoneal macrophages deficient for SAMHD1 and IFNAR

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SAMHD1 is a phospho-regulated Rnase that is essential for restricting HIV-1 infection through direct cleavage of HIV-1 genomic RNA

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