Comparison of gene expression in NOD versus NOD.NOR-Chr4 (NR4) splenic B cells.

ABSTRACT: Type 1 Diabetes (T1D) in humans and the non-obese diabetic (NOD) mouse model results from autoreactive T cell destruction of pancreatic beta cells. A pathogenic role for B lymphocytes (B cells) in T1D first became evident when NOD mice made deficient in this population through introduction of an inactivated IgM-BM-5 heavy chain gene (NOD.IgM-BM-5null) or chronic treatment with anti-IgM antibodies were strongly protected from disease. We produced an NOD background strain developing a greatly decreased T1D incidence due to a NOR-derived 44.31Mb congenic region from rs3674285 to D4Mit127 on distal Chr. 4 (termed NOD.NOR-Chr4 (NR4)) containing disease resistance alleles decreasing the pathogenic activity of autoreactive B cells. Microarrays were conducted on B cells purified from spleens of NO

ORGANISM(S): Mus musculus

SUBMITTER: Pablo Silveira 

PROVIDER: E-GEOD-37294 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress