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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Insecticide resistance mechanisms Myzus persicae: Genotypes Insecticide vs. Genotypes Control

ABSTRACT: Transcripcional responses in three genotypes of Muzus persicae, each exhibiting different resistance mechanisms, in response to an anti.cholinesterase insecticide Two-condition experiment in threee different genotypes: Insecticide vs. acetone plus water. Genotypes S (exhibiting no resistance mechanism) Biological replicates: 3. Genotypes RS (resistant through a kdr sodium channel mutation) Biological replicates: 2. Genotypes MR (carrying kdr and MACE mutations) Biological replicates: 2.

ORGANISM(S): Myzus persicae

SUBMITTER: Andrea Silva

PROVIDER: E-GEOD-37310 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Insecticide resistance mechanisms Myzus persicae: Genotypes Insecticide vs. Genotypes Control

Project description:Transcripcional responses in three genotypes of Muzus persicae, each exhibiting different resistance mechanisms, in response to an anti.cholinesterase insecticide

2013-01-01 | GSE37310 | GEO

Transcriptome responses to defined insecticide selection pressures in the German cockroach

Project description:Purpose: Next-generation transcriptome sequencing was done to understand host and eukaryotic microbiome changes in gene expression in association with defined insecticide selection pressures. The specific goal of this research was to understand whole-body physiological responses in German cockroaches and associated microbiota, at the metatranscriptome level, to defined insecticide selection pressures. Methods: We used the insecticide indoxacarb as the selecting insecticide, which is an important bait active ingredient for cockroach control. Six generations of selection with indoxacarb bait produced a strain with substantial (>20x) resistance relative to inbred control lines originating from the same parental stock. Results: Metatranscriptome sequencing revealed 1123 significantly differentially expressed genes in > two of three statistical models (81 upregulated and 1042 downregulated; FDR p<0.001; log2FC of +/- 1). The majority of upreglated genes were from the host cockroach while the majority of downregulated genes were from associated viruses and the eukaryotic microbiome. Conclusions: We show here significant impacts by insecticide selection on not only host stress-respnses like detoxification, but also on clearace of microbial parasites, pathogens, commensals and/or symbionts.

2021-12-07 | GSE188950 | GEO

Myzus persicae

Project description:Insecticide resistance mechanisms Myzus persicae: Genotypes Insecticide vs. Genotypes Control

| PRJNA159425 | ENA

ER71/ETV2-mediated direct reprogramming of human dermal fibroblasts (HDFs) into endothelial-like cells

Project description:Samples 1-6: HDFs transduced with ER71/ETV2 were sorted on KDR expression at day 7. The isolated KDR+ cells together with human umbilical venous endothelial cells (HUVECs) and untransduced HDFs were subjected to genomic gene expression profiling. A significant number of genes related with vessel development and angiogenesis was significantly upregulated in KDR+ cells, compared to control HDFs. These findings strongly argue that ER71/ETV2 directly reprograms human fibroblasts to functional endothelial-like cells, which could be useful for disease investigation as well as autologous cell therapy. Samples 7-12: HDFs transduced with ER71/ETV2 were sorted on KDR expression at day 7. The isolated KDR+ cells were further cultured up to day 93. The further cultured cells together with human umbilical venous endothelial cells (HUVECs) and untransduced HDFs were subjected to genomic gene expression profiling. A significant number of genes related with vessel development and angiogenesis was significantly upregulated in the further cultured cells, compared to control HDFs. These findings strongly argue that ER71/ETV2 directly reprograms human fibroblasts to functional endothelial-like cells, which could be useful for disease investigation as well as autologous cell therapy. Samples 1-6: HDFs transduced with ER71/ETV2 were sorted on KDR expression at day 7. The isolated KDR+ cells together with human umbilical venous endothelial cells (HUVECs) and untransduced HDFs were subjected to genomic gene expression profiling. Samples 7-12: HDFs transduced with ER71/ETV2 were sorted on KDR expression at day 7. The isolated KDR+ cells were further cultured up to day 93. The further cultured cells together with human umbilical venous endothelial cells (HUVECs) and untransduced HDFs were subjected to genomic gene expression profiling.

2013-09-12 | E-GEOD-50801 | biostudies-arrayexpress

Comparative analysis of Papaver somniferum genotypes having contrasting latex and alkaloid profiles

Project description:Sampada and Sujata are two contrasting genotypes of Papaver somniferum that are contrasting in terms of their latex and alkaloid profiles. The major objective of the present study was to use a small-scale (750 target genes) microarray of P. somniferum for identification of genes that are differentially expressed in the capsule walls of the two contrasting genotypes, Sampada and Sujata. Nidarshana Chaturvedi and Mridula Singh made equal contribution as first authors to this data. The experiment aimed at studying the expression levels of target genes in P. somniferum. A dual channel procedure with dye-swap arrangement was adopted in the study on two samples - Sampada and Sujata. The interest was to compare the expression levels of target genes in Sujata against Sampada. The expression data was generated on 1,569 probes, which includes controls and target probes.

2013-12-30 | E-GEOD-37983 | biostudies-arrayexpress

Genome-wide gene expression profiling of three Ethiopian insecticide resistant Anopheles arabiensis populations and two insecticide susceptible Anopheles arabiensis strains

Project description:Illumina HiSeq 2500 technology was used to sequence the transcriptome of three Ethiopian field populations of An. arabiensis (Asendabo (ASN), Chewaka (CHW) and Tolay (TOL)) and two An. arabiensis strains (Sekoru (SEK, from Ethiopia) and Moz (MOZ, from Mozambique)). Both ASN, CHW and TOL were previously shown to be resistant against delamethrin and DDT, while the two An. arabiensis strains (SEK and MOZ) were both susceptible to deltamethrin and DDT (Alemayehu et al. 2017, DOI: 10.1186/s13071-017-2342-y; Witzig et al. 2013, DOI: 10.1038/hdy.2012.112). Differentially expressed genes (absolute fold change (FC) ≥ 2 and Benjamini-Hochberg adjusted p-value < 0.05) were determined between each insecticide resistant field population (ASN, CHW or TOL) and one of the insecticide susceptible strains (SEK or MOZ).

2019-03-20 | GSE121006 | GEO

Drosophila gene expression in response to the botanical insecticide Piper nigrum

Project description:This experiment was used to determine the effect of a botanical insecticide upon gene expression profiles in Drosophila melanogaster. Adult female Drosophila (oregon-R strain) were treated with an ethylacetate extract of Piper nigrum (Piperaceae) seeds formulated in 99% ethanol. Treatment was topical, using a Potter's tower to administer a total of 2 mL of a 0.9mg/mL concentration. Control treatment was identical except flies were treated with 99% ethanol as a solvent control. Gene expression was studied four hours post-treatment. Keywords: insecticide response, stress-response

2006-01-24 | GSE3032 | GEO

Protein profiles Insecticide resistant Ae. aegypti

Project description:Protein profiles of insecticide resistance Ae. aegypti in Penang island, Malaysia

2022-04-14 | MSV000089259 | MassIVE

Impact of environmental pollutants on insecticide-driven gene selection in mosquitoes

Project description:This microarray study aimed at evaluating the impact of mosquito chemical environment on the selection of insecticide resistance mechanisms. Here the mosquito Aedes aegypti was used as a model to perform a laboratory experiment combining mosquito larvae exposure to a sub-lethal dose of xenobiotic and their selection with the insecticide permethrin. After ten generations, bioassays and a transcriptome profiling with the 15K microarray Aedes detox chip plus microarray were performed comparatively on all strains.

2012-03-31 | E-MTAB-632 | biostudies-arrayexpress

Blood feeding response of insecticide resistant mosquitoes from Ghana, GAH strain

Project description:Anopheles gambiae S form adults were drawn from the GAH laboratory colony that originated from the Ahafo region in Ghana. The GAH colony exhibits extensive insecticide resistance (bendiocarb, DDT, dieldrin, permethrin, deltamethrin). Gene expression was compared between blood-fed and sugar-fed females (3 hours after feeding) using a custom array focussing on around 300 detoxification-related genes.

2013-08-30 | E-MTAB-1621 | biostudies-arrayexpress

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