Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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TET2 loss-of-function mutations associate with a DNA hypermethylation signature in diffuse large B-cell lymphoma (DNA methylation)

ABSTRACT: Genome wide DNA methylation profiling of patient samples with TET2 mutations and Wild type TET2 status . The Illumina Infinium HumanMethylation 450_15017482_v.1.1 was used to obtain DNA methylation profiles across approximately 482,421 CpGs in fresh frozen lymphoma samples. Samples include 19 TET2 wild type and 12 TET2 mutant samples. Bisulphite converted DNA from the 31 samples were hybridised to the Illumina Infinium HM450K Human Methylation Beadchip v1.2

ORGANISM(S): Homo sapiens

SUBMITTER: Vasu Punj 

PROVIDER: E-GEOD-37362 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma.

Asmar Fazila F   Punj Vasu V   Christensen Jesper J   Pedersen Marianne T MT   Pedersen Anja A   Nielsen Anders B AB   Hother Christoffer C   Ralfkiaer Ulrik U   Brown Peter P   Ralfkiaer Elisabeth E   Helin Kristian K   Grønbæk Kirsten K  

Haematologica 20130705 12

The discovery that the Ten-Eleven Translocation (TET) hydroxylases cause DNA demethylation has fundamentally changed the notion of how DNA methylation is regulated. Clonal analysis of the hematopoetic stem cell compartment suggests that TET2 mutations can be early events in hematologic cancers and recent investigations have shown TET2 mutations in diffuse large B-cell lymphoma. However, the detection rates and the types of TET2 mutations vary, and the relation to global methylation patterns has  ...[more]

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