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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from human colonic biopsy samples (adenoma-carcinoma)

ABSTRACT: Whole genomic microarray analysis was performed in order to identify gene expression profile alterations focusing on the dysplastic adenoma-carcinoma transition. Our aims were to determinate characteristic transcript sets for developing diagnostic mRNA expression patterns for objective classification of benign and malignant colorectal diseases and to test the classificatory power of these markers on an independent sample set. Total RNA was extracted from colonic biopsy samples of histologically negative patients and of patients with adenoma or colorectal cancer and were hybridized on Affymetrix HGU133 Plus 2.0 microarrays

ORGANISM(S): Homo sapiens

SUBMITTER: Wichmann Barna

PROVIDER: E-GEOD-37364 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression data from human colonic biopsy samples (adenoma-carcinoma)

Project description:Whole genomic microarray analysis was performed in order to identify gene expression profile alterations focusing on the dysplastic adenoma-carcinoma transition. Our aims were to determinate characteristic transcript sets for developing diagnostic mRNA expression patterns for objective classification of benign and malignant colorectal diseases and to test the classificatory power of these markers on an independent sample set.

2013-01-01 | GSE37364 | GEO

Expression data from human colonic biopsy samples

Project description:Age-related transcriptome changes can contribute to better understanding of gastrointestinal disorders such as colorectal cancer in older population Total RNA was extracted from colonic biopsy samples from histologically normal children and the samples were hybridized on Affymetrix HGU133 Plus 2.0 microarrays

2013-01-01 | E-GEOD-37267 | biostudies-arrayexpress

Transcription profiling of peripheral blood samples from patients with Crohn's disease (CD) and Ulcerative colitis (UC) .

Project description:The whole-genome oligonucleotide microarray analysis of peripheral blood samples can contribute to the determination of distant blood markers of local pathophysiological alterations in colorectal diseases. These markers can lead to alternative screening procedures. Total RNA was extracted from peripheral blood samples of patients with Ulcerative colitis (UC) and Crohn's disease (CD) and hybridized on Affymetrix HGU133 Plus 2.0 microarrays

2009-05-19 | E-GEOD-11499 | biostudies-arrayexpress

Expression data from normal and CRC human peripheral blood samples

Project description:The whole-genome oligonucleotide microarray analysis of peripheral blood samples can contribute to the determination of distant blood markers of local pathophysiological alterations in colorectal diseases. These markers can lead to alternative screening procedures. Keywords: whole genomic expression Total RNA was extracted from peripheral blood samples of healthy patients and patients with CRC and hybridized on Affymetrix HGU133 Plus 2.0 microarrays

2009-01-29 | E-GEOD-10715 | biostudies-arrayexpress

Expression data from human colonic epithelial cells normal (N), adenoma (AD) or colorectal cancer (CRC) tissues

Project description:The whole-genome oligonucleotide microarray analysis of laser microdissected human colonic epithelial cells can contribute to determination of disease-specific expression alterations in colonic epithelial cells and to localize the origin the expression changes measured in whole biopsy samples. Keywords: whole genomic expression Total RNA was extracted from laser microdissected human colon epithelial cells and hybridized on Affymetrix HGU133 Plus 2.0 microarrays

2010-03-15 | E-GEOD-15960 | biostudies-arrayexpress

Expression data from human HT-29 immortalized colorectal adenocarcinoma cell line

Project description:Gene expression profiling for identification of genes regulated by DNA methylation Total RNA was extracted from HT-29 cell line was hybridized on Affymetrix HGU133 Plus 2.0 microarrays

2012-01-01 | E-GEOD-29060 | biostudies-arrayexpress

Expression data from human HT29, HDFa cell lines after normal and tumor tissue derived DNA treatment

Project description:Gene expression profile based on human HT29, HDFa cell lines after normal and tumor tissue derived DNA treatment Total RNA was extracted from human HT29, HDFa cell lines after normal and tumor tissue derived DNA treatment were hybridized on Affymetrix HGU133 Plus 2.0 microarrays

2015-06-11 | E-GEOD-67557 | biostudies-arrayexpress

Expression data from human colonic biopsy sample

Project description:Gene expression profile based classification of colonic diseases are suitable for identification of diagnostic mRNA expression patterns which can establish the basis of a new molecular biological diagnostic method Keywords: whole genomic expression Total RNA was extracted from colonic biosy samples CRC and hybridized on Affymetrix HGU133 Plus 2.0 microarrays

2009-01-29 | E-GEOD-10714 | biostudies-arrayexpress

Expression data from human peripheral blood samples

Project description:Gene expression profile based classification of colonic diseases are suitable for identification of diagnostic mRNA expression patterns which can establish the basis of a new molecular biological diagnostic method. Keywords: whole genomic expression Total RNA was extracted from peripheral blood samples Diverticulitis and Infective colitis were hybridized on Affymetrix HGU133 Plus 2.0 microarrays.

2011-03-01 | E-GEOD-21826 | biostudies-arrayexpress

Identification of an intermediate signature that marks the initial phases of colorectal adenoma-carcinoma transition

Project description:The colorectal adenoma-carcinoma sequence describes the stepwise progression from normal to dysplastic epithelium and then to carcinoma; only a small proportion of colorectal adenoma (CRA) progresses to colorectal carcinoma (CRC). Presently, endoscopic intervention is used on patients with CRAs of high grade dysplasia, diameters > 1 cm, or villous components > 25% who are at higher risk than other CRA sufferers. During the process, biopsy samples were taken for conventional histological diagnosis, but poor pathomorphological sensitivity and specificity greatly limit the diagnostic accuracy. Unfortunately, there are no reliable molecular criteria available that can predict the potential development of CRA to CRC. In present study, we use microarrays to detail the global programme of gene expression underlying the gradual progress of colorectal adenoma-carcinoma sequence.

2010-08-29 | GSE22242 | GEO

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