Function, targets and evolution of Caenorhabditis elegans piRNAs
Ontology highlight
ABSTRACT:
ORGANISM(S): Caenorhabditis elegans
SUBMITTER: Leonard Goldstein
PROVIDER: E-GEOD-37433 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Function, targets, and evolution of Caenorhabditis elegans piRNAs.
Bagijn Marloes P MP Goldstein Leonard D LD Sapetschnig Alexandra A Weick Eva-Maria EM Bouasker Samir S Lehrbach Nicolas J NJ Simard Martin J MJ Miska Eric A EA
Science (New York, N.Y.) 20120614 6094
Piwi-interacting RNAs (piRNAs) are small RNAs required to maintain germline integrity and fertility, but their mechanism of action is poorly understood. Here we demonstrate that Caenorhabditis elegans piRNAs silence transcripts in trans through imperfectly complementary sites. Target silencing is independent of Piwi endonuclease activity or "slicing." Instead, piRNAs initiate a localized secondary endogenous small interfering RNA (endo-siRNA) response. Endogenous protein-coding gene and transpos ...[more]
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