Molecular Phenotyping of Immune Cells from Young NOD Mice

ABSTRACT: Islet leukocytic infiltration (insulitis) is first obvious at around 4 weeks of age in the NOD mouse – a model for human type 1 diabetes (T1DM). The molecular events leading to insulitis are poorly understood. Since TIDM is caused by numerous genes, we hypothesized that multiple molecular pathways are altered and interact to initiate this disease. Analysis of the global gene expression profiles using microarrays followed by hierarchical clustering revealed that the majority (~90%) of the differentially expressed genes in NOD mice relative to control mice were repressed. Further analysis of these genes using a modern suite of multiple bioinformatics approaches identified abnormal molecular pathways that can be divided broadly into 2 categories: metabolic pathways, which were predominant at

ORGANISM(S): Mus musculus

SUBMITTER: Dorothy Kakoola 

PROVIDER: E-GEOD-37450 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress