Serum miRNA profiles of patients with oral cancer and pre-cancer

ABSTRACT: The aim of this study was to examine the expression profiles of circulating miRNAs in the serum of patients with high-risk oral lesions (HRLs; oral cancer or carcinoma in situ) and to explore their utility as potential oral cancer biomarkers. Global serum miRNA profiles were generated by quantitative PCR method from 1) patients diagnosed with HRLs and undergoing intent-to-cure surgical treatment (N = 30) and 2) a demographically-matched, normal control group (N = 26). We next honed our list of serum miRNAs associated with disease by reducing the effects of inter-patient variability; we compared serum miRNA profiles from samples taken both before and after tumor resections (N = 10). Based on these analyses, fifteen miRNAs were significantly up-regulated and five were significantly down-regu

ORGANISM(S): Homo sapiens

SUBMITTER: Sara MacLellan 

PROVIDER: E-GEOD-37472 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress