CSF-1R inhibition alters macrophage polarization and blocks gliomagenesis

ABSTRACT: Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor in adults, can be divided into several molecular subtypes including proneural GBM. Most clinical strategies aimed at directly targeting glioma cells in these tumors have failed. A promising alternative is to target stromal cells in the brain microenvironment, such as tumor-associated microglia and macrophages (TAMs). Macrophages are dependent upon colony stimulating factor (CSF)-1 for differentiation and survival; therefore, we used an inhibitor of its receptor, CSF-1R, to target macrophages in a mouse proneural GBM model. CSF-1R inhibition dramatically increased survival in mice and regressed established GBMs. Tumor cell apoptosis was significantly increased, and proliferation and tumor grade markedly decrea

ORGANISM(S): Mus musculus

SUBMITTER: Robert Bowman 

PROVIDER: E-GEOD-37475 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress