Time course of gene expression changes after muscle contraction in spinal cord injured rats

ABSTRACT: Purpose: The goal of this study was to determine the gene expression changes that occur over 7 days in parralyzed muscle in response to isometric contraction elicited by electrical stimulation initiated 4 months after spinal cord injury and to compare such changes to those observed in a normal muscle subjected to overload. Methods: Electrical stimulation of the soleus and plantaris muscle was stimulated in female rats with complete transection of the spinal cord at the interspace between the 9th and 10th thoracic vertebrae. Stimulation was begun 16 weeks after spinal cord transection and produced near-isometric contraction of soleus, plantaris and tibialis anterior. Muscle was analyzed at 1, 2 and 7 days after starting exercise with electrical stimulation. To provide a baseline referenc

ORGANISM(S): Rattus norvegicus

SUBMITTER: christopher cardozo 

PROVIDER: E-GEOD-37476 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress