Regulation of synovial DKK1 expression by local glucocorticoid metabolism in inflammatory arthritis

ABSTRACT: Inflammatory arthritis is associated with bone loss and fractures due to abnormal bone remodelling. Bone remodelling is 'uncoupled' with bone resorption increased and bone formation suppressed. These changes resemble those seen in patients treated with therapeutic glucocorticoids, and in both of these situations, altered wnt signalling is implicated. Recent studies have highlighted the importance of the synovial fibroblast in mediating abnormal bone remodelling during inflammation. The wnt antagonist dickkopf-1 (DKK1) is secreted by synovial fibroblasts in response to inflammation, and this protein has been proposed to be a master regulator of bone remodelling in inflammatory arthritis. Here we show that DKK1 expression by primary human synovial fibroblasts is more potently regulated by gl

ORGANISM(S): Homo sapiens

SUBMITTER: Rowan Hardy 

PROVIDER: E-GEOD-37520 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress