RNA-seq analysis of differential gene expression in liver from lactating dairy cows divergent in negative energy balance

ABSTRACT: Background: The liver is central to most economically important metabolic processes in cattle. However, the changes in expression of genes that drive these processes remain incompletely characterised. RNA-seq is the new gold standard for whole transcriptome analysis but so far there are no reports of its application to analysis of differential gene expression in cattle liver. We used RNA-seq to study differences in expression profiles of hepatic genes and their associated pathways in individual cattle in either mild negative energy balance (MNEB) or severe negative energy balance (SNEB). NEB is an imbalance between energy intake and energy requirements for lactation and body maintenance. This aberrant metabolic state affects high-yielding dairy cows after calving and is of considerable eco

ORGANISM(S): Bos taurus

SUBMITTER: Chris Creevey 

PROVIDER: E-GEOD-37544 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress