Effect of small molecules on activated astrocytes

ABSTRACT: We have developed an assay to test the neuroprotective properties of compounds using stem cellM-bM-^@M-^Sderived motor neurons and astrocytes, together with activated microglia as a stress paradigm. Hit compounds were discovered and the transcriptional response on activated astrocytes cells was tested. Neural stem cell (NSC)-derived astrocytes (AC) were activated with LPS and IFN-M-NM-3 and treated with hit compound for 4 hr.

ORGANISM(S): Mus musculus

SUBMITTER: Susanne HM-CM-6ing 

PROVIDER: E-GEOD-37611 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress