Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Effect of small molecules on activated astrocytes and microglia cells


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE37611: Effect of small molecules on activated astrocytes GSE37612: Effect of small molecules on activated BV2 microglia cell line Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Susanne HM-CM-6ing 

PROVIDER: E-GEOD-37613 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay.

Höing Susanne S   Rudhard York Y   Reinhardt Peter P   Glatza Michael M   Stehling Martin M   Wu Guangming G   Peiker Christiane C   Böcker Alexander A   Parga Juan A JA   Bunk Eva E   Schwamborn Jens C JC   Slack Mark M   Sterneckert Jared J   Schöler Hans R HR  

Cell stem cell 20121011 5


Stem cells, through their ability to both self-renew and differentiate, can produce a virtually limitless supply of specialized cells that behave comparably to primary cells. We took advantage of this property to develop an assay for small-molecule-based neuroprotection using stem-cell-derived motor neurons and astrocytes, together with activated microglia as a stress paradigm. Here, we report on the discovery of hit compounds from a screen of more than 10,000 small molecules. These compounds ac  ...[more]

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