Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles

ABSTRACT: Breast cancer is a heterogeneous disease for which prognosis and treatment strategies are largely governed by the receptor status (estrogen, progesterone and Her2-neu) of the tumor cells. Gene expression profiling of whole breast tumors further stratifies breast cancer into several molecular subtypes which also co-segregate with the receptor status of the tumor cells. We postulated that cancer associated fibroblasts (CAFs) within the tumor stroma may exhibit subtype specific gene expression profiles and thus contribute to the biology of the disease in a subtype specific manner. Several studies have reported gene expression profile differences between CAFs and normal breast fibroblasts but in none of these studies were the results stratified based on tumor subtypes. To address whether ge

ORGANISM(S): Homo sapiens

SUBMITTER: Louise Showe 

PROVIDER: E-GEOD-37614 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress