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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transciptome analysis of Salmonella enterica serovar Typhimurium UK1 delta-rsiM at oxidative stress

ABSTRACT: Salmonella has various mechanisms of small RNA-mediated gene regulation. In Salmonella enterica serovar Typhimurium, a novel intergenic transcript RsiM is involved in oxidative stress response which functions as one of the powerful antimicrobials in macrophage innate immunity. We note that the M-bM-^HM-^FrsiM mutant is sensitive to hydrogen peroxide (5.0mM). This finding provides insights into the function of RsiM as a regulator of oxidative stress response. UK1 wild-type and M-bM-^HM-^FrsiM strains were grown in LB medium at 37M-bM-^DM-^C to an OD600 of 0.6, and then subjected to oxidative stress (5.0 mM hydroperoxide) for 30 min. Total RNA was extracted from three biological replicates of wild-type and M-bM-^HM-^FrsiM mutant.

ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1

SUBMITTER: Yong Keun Park

PROVIDER: E-GEOD-37626 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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