The peripheral genome-wide gene expression profiles in humans after prolonged wakefulness and sleep recovery

ABSTRACT: Although the specific functions of sleep have not been completely elucidated, the literature has suggested that sleep is essential for proper homeostasis. Sleep loss is associated with changes in behavioral, neurochemical, cellular, and metabolic functions as well as impaired immune response. We evaluated the gene expression profiles of healthy volunteers submitted to 48 hours of prolonged wakefulness (PW) followed by 12 hours of sleep recovery (SR) using high-resolution microarrays. Peripheral whole blood was collected in the morning before the initiation of sleep deprivation (baseline), after the second night of PW, and one night after SR. the identified differentially expressed genes were related to immune response, DNA damage and repair as well as inflammation. Examples of these includ

ORGANISM(S): Homo sapiens

SUBMITTER: Renata Pellegrino 

PROVIDER: E-GEOD-37667 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress