Genome-wide analysis of the cytosine methylation profile in Arabidopsis thaliana crown galls

ABSTRACT: Integration of the bacterial T-DNA into the plant genome by virulent agrobacteria causes crown gall development on many plant species. Plant tumor development shares fundamental similarities with mammalian cancer progression despite obvious differences in initiation of tumor development. For neoplastic growth in mammals, DNA methylation changes are known to be essential. The role of epigenetic modifications for plant tumor development is addressed here. Genome-wide comparison of methylation profiles of Arabidopsis crown galls and tumor-free tissue revealed 2,876 annotated genes that were affected by differential methylation. Thereof, 1,822 genes were hit by hypermethylated regions and 1,100 genes overlapped with hypomethylated regions (sum of hyper-and hypomethylated genes is higher than t

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Claus Scholz 

PROVIDER: E-GEOD-37680 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress