Identification of an intrahepatic transcriptional signature associated with self-limiting infection in the woodchuck model of hepatitis B

ABSTRACT: The woodchuck model of hepatitis B virus (HBV) infection displays many characteristics of human infection and has particular value for characterizing the host immune responses during the development of chronic infection. Using the newly developed custom woodchuck microarray platform, we compared the intrahepatic transcriptional responses of neonatal woodchucks with self-limiting and progressing persistent infection with woodchuck hepatitis virus (WHV). This revealed that WHV does not induce intrahepatic gene expression during the early acute stage of infection (8 weeks), suggesting it is a M-bM-^@M-^\stealthM-bM-^@M-^] virus. At the mid-acute phase of infection (14 weeks), resolution was associated with induction of a prominent cytotoxic T cell signature, with perforin and other markers of

ORGANISM(S): Marmota monax

SUBMITTER: Donavan Cheng 

PROVIDER: E-GEOD-37683 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress