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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from Drosophila S2 cells

ABSTRACT: An Affimetrix GeneChip Drosophila genome 2.0 array was used to study the effect of protocatechuic aldehyde on gene expression. The addition of 0.1 mM protocatechuic aldehyde to Drosophila S2 cells significantly affected the expression of 52 genes, with 29 being up-regulated and 23 being down-regulated. Drosophila S2 cells were incubated with protocatechuic aldehyde (0.1 mM). After 2 hr, the gene expression in Drosophila S2 cells was analyzed using Affymetrix microarrays.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Sato Yukiko

PROVIDER: E-GEOD-37701 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Pharmacological modulation of histone demethylase activity by a small molecule isolated from subcritical water extracts of Sasa senanensis leaves prolongs the lifespan of Drosophila melanogaster.

Nakagawa-Yagi Yuzo Y Sato Yukiko Y Matsumoto Emi E Nakatsuka Shin-Ichi S Sakaki Tsuyoshi T Muramatsu Yukiko Y Hara Takaaki T Aigaki Toshiro T

BMC complementary and alternative medicine 20120718

<h4>Background</h4>Extracts of Sasa senanensis Rehder are used in traditional Japanese medicine; however, little is known about the underlying mechanisms of their potential health benefits.<h4>Methods</h4>S. senanensis leaves were extracted with subcritical water. An active small-molecule was isolated using reversed-phase high-performance liquid chromatography (HPLC), and identified as 3,4-dihydroxybenzaldehyde (protocatechuic aldehyde or PA). The effects of PA on the activity of histone demethy ...[more]

PMID: 22809229

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Expression data from Drosophila S2 cells

Project description:An Affimetrix GeneChip Drosophila genome 2.0 array was used to study the effect of protocatechuic aldehyde on gene expression. The addition of 0.1 mM protocatechuic aldehyde to Drosophila S2 cells significantly affected the expression of 52 genes, with 29 being up-regulated and 23 being down-regulated.

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